Oriaifo S. E., Omogbai E. K. I. and Nicholas Oriaifo
The aim of the study was to identify the pattern of active behaviours exhibited by the agents’ sertraline, imipramine, nifedipine, furosemide and bumetanide in the forced swim test (FST) using mice. Six groups of mice (six mice in each group) were used in the study of swimming times and climbing times. A control group received Tween 80. Other groups were treated with imipramine (10mg/kg), sertraline (5mg/kg), nifedipine (5mg/kg), furosemide (10mg/kg) and bumetanide (2.5mg/kg) acutely, subchronically for 14 days and chronically for 30 days. A study with the FST was done acutely, on the 15th day and on the 31st day. Results showed that sertraline prolonged swimming times and in the same breath decreased climbing times acutely, subchronically and chronically significantly (P < 0.05, < 0.01) compared to control values. Imipramine prolonged swimming times acutely, subchronically and chronically but increased climbing times only when given chronically. Nifedipine prolonged swimming times significantly only when given subchronically and chronically, and did not affect climbing times. Bumetanide only prolonged swimming times significantly when given chronically while furosemide did not affect swimming times but prolonged climbing times acutely, subchronically and chronically significantly when compared to control values (P < 0.05, < 0.01). In conclusion, the results suggest that serotonin may affect multiple and complex signal transduction pathways; imipramine the serotonergic and noradrenergic signalling, nifedipine and bumetanide the serotonergic signalling and furosemide the noradrenergic signalling for their respective effects.
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