+44 3308180992Sashank Reddy Y*, L Inbathamizh
The exact cause of Alzheimer's disease is unknown, but researchers believe it's a complex interplay of genetic, environmental, and lifestyle factors. Age is the biggest risk factor, with the risk increasing after 65. Alzheimer's disease is caused by the abnormal build-up of proteins in and around brain cells. One of the proteins involved is called amyloid, deposits of which form plaques around brain cells. The other protein is called tau, deposits of which form tangles within brain cells. Alzheimer's disease patients' neurotic plaques are mostly made up of Aβ, a 4-kDa peptide generated from the amyloid precursor protein. Evidence suggests that Aβ plays a significant role in the pathophysiology of the disease. Potential therapies that target Aβ synthesis or accumulation in the brain as β-amyloid are being vigorously researched. Quantifying the Aβ peptide is crucial for studying the disease's underlying genesis and evaluating prospective therapies. The Enzyme-Linked Immunosorbent Assay (ELISA) is a reliable and widely used method for measuring Aβ in the brains of Alzheimer's patients and transgenic mice with β-amyloid deposition.
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