Oluwole I. Oyewole
Studies have shown that potassium bromate induces a cute renal damage arising from oxidative stress in man. The present study was undertaken to examine the effect of vitamin C and E on potassium bromate induced toxicity in rat kidney. Wistar albi no rats were grouped into four (A, B, C and D) and administered 10mg/kg bw potassium bromate daily for 21 days (Group A serves as the control and received distilled water instead of potassium broma te). Group C and D were treated with intraperitoneal administration of vitamin C (40mg/k g bw) and vitamin E (20mg/kg bw) respectively while group B were left untreated. Antioxidant and prooxidant levels were measured in the kidney in addition to analysis of kidney function parameters in the serum. Potassium bromate caused significant depletion in antioxidant enzymes in the kidney as we ll as elevation in thiobarbituric acid reactive substances (TBARS). Serum urea and creatinine were also elevated in rats administered with potassium bromate indicative of nephritic malfuncti on. Rats treated with vitamin C and E showed significant improvement in renal antioxidant capaci ty and restoration of kidney function. This study suggests that vitamin C and E has protective role o n potassium bromate induced renal oxidative damage in rat.
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