Antibiotic susceptibility pattern of uropathogenic bacterial | 18121
International Research Journals

Antibiotic susceptibility pattern of uropathogenic bacterial isolates from Aids patients in a Nigerian tertiary hospital.


S.I. Nwadioha, EOP Nwokedi, I. Ikeh, J. Egesie, E. Kashibu

To determine the antibiotic susceptibility pattern of bacterial isolates causing urinary tract infecti ons in AIDS patients, 500 AIDS patients and 500 non-AIDS p atients (served as control) each on admission were recruited into the study between 2007 and 2008 in Aminu Kano Teaching Hospital, Kano, Nigeria. Urine samples were collected with sterile universal bottles and analysed with appropriate laboratory methods and antibiotic susceptibility test was carr ied out by disk diffusion technique in accordance with CLSI (formerly, NCCLS) criteria, 2006. The res ults were analyzed using SPSS 11.0 statistical software, p-value <0.05 were considered significant at 95% confident limit. Escherichia coli were the most common isolate in the both groups. A wider spe ctrum of micro-organisms were isolated from AIDS group patients compared to control group. Most of the urinary bacterial isolates (n=350) from bot h groups were highly sensitive to ceftazidime (95%) an d ciprofloxacin (88%). There was generally low sensitivity of bacterial isolates to most antibioti cs in common use such as co-trimoxazole (40%), tetracycline (25%), chloramphenicol (33%) and ampic illin (40%) with no significant difference between the AIDS and control group. There was no significan t difference in the antibiotic susceptibility patte rn between the AIDS group and the control group in the study. Rational use of antibiotics with regular antibiotics susceptibility surveillance studies is recommended to maintain high antibiotic therapeutic profile

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