International Research Journal of Biotechnology

Alternative Splice Variants in Gene Expression Values in Patients with Marfan???s Syndrome

Abstract

Wouter Ouwerkerk

Alternative splicing of messenger RNAs provides cells with the opportunity to create protein isoforms of a multitude of functions from a single gene by excluding or including exons during posttranscriptional processing. Reconstructing the contribution of these splice variants on the total amount of gene expression remains difficult. We introduced a probabilistic formulation of the alternative splicing reconstruction problem using a finite mixture model, and provide a solution based on the maximum likelihood principle.

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