A possible protective role of glucose-6-phosphate dehydrogen | 17966
International Research Journals

A possible protective role of glucose-6-phosphate dehydrogenase deficiency and sickle haemoglobin genes against severe malaria in Madonna University, Elele Community


Francis M. Awah, Nwanedo Chukwuemeka G., Salami Ibrahim Olalekan, Augusta Ehijie Azeke, Mbaike Nneka

The high frequency of the enzymopathy, glucose-6-pho sphate dehydrogenase (G6PD) deficiency and haemoglobinopathy, sickle cell haemoglobin (HbS) in malaria endemic regions is believed to be due to a heterozygous advantage against severe malaria. How ever, data to prospectively confirm the selective protection in different regions are lacking. In thi s study, the frequency of these genetic defects, th eir extent of interaction and contribution to severe ma laria protection was investigated in Madonna University community. The methaemoglobin method was used to determine the G6PD status while haemoglobin genotype was determined using cellulose acetate paper electrophoresis with Tris-EDTA- borate buffer (pH 8.9)

Share this article