Mini Review
Multiple DNA/RNA sequence alignment and phylogenetic tree-building programme called SaAlign for extremely huge datasets and extremely lengthy sequences
Author(s): Jung Cook*
Multiple DNA/RNA sequence alignment is a crucial bioinformatics foundational technique, particularly for the creation of phylogenetic trees. The volume of bioinformatics data is continuously growing as a result of advancements in DNA-sequencing, necessitating the continuous iteration of several tools. Bioinformatics software is needed to analyse the mitochondrial genomes of various people and species, thus its performance has to be improved. We used longest common substring techniques to optimise a dynamic programming solution for the alignment of extremely big datasets and extremely lengthy sequences (Liou et al., 2013). The Multiple DNA/ RNA Sequence Alignment Tool Based on Suffix Tree (SaAlign), which aligns sequences of diverse lengths, some exceeding 300 kb (kilobases), was shown to save time and computing space on extremely large test DNA datasets. It performed better than the a.. View More»
DOI:
10.14303/2250-9941.2022.37