The tricarboxylic acid (TCA) cycle, often known as the Krebs cycle, is a critical metabolic system that oxidizes foods to sustain cellular bioenergetics. Recently, it has become clear that TCA cycle activity is dynamic, and that TCA cycle products can be co-opted in cancer and other pathologic situations. We explore the TCA cycle in this overview, including its possible beginnings and the history of its discovery (Elmlinger et al., 2002). TCA (Tricarboxylic Acid) Cycle "TCA cycle is a series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl CoA derived from carbohydrates, fats, and proteins into ATP." The TCA cycle, also known as the Tricarboxylic Cycle, is also known as Kreb's Cycle or the Citric Acid Cycle (Soldin et al., 2005).
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