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The Effect of Zinc and aluminum chloride in lactation period on coordination and motor activity of parents and their offspring| Abstract

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The Effect of Zinc and aluminum chloride in lactation period on coordination and motor activity of parents and their offspring

Abstract

Ehsani Vostacolaee Simin, Karami Mohammad, Moazedi Ahmad Ali, Alemi Rostami Sharbano

In the present study, the effects of zinc and alumin um chloride administration on coordination and motor activity of their male and female offspring h ave been investigated by using Rotarod for assess animal’s motor activity and coordination. Aluminum administered as AlCl 3 (0, 200, 400, 600, 800 mg/kg/day) and zinc as znCl 2 (0, 20, 30, 50, 70, 100 mg/kg/day) in drinking wat er for two weeks during lactation, and their female and male offspring were tested respectively after 44 days and one month. The results showed that maternal dietary exposure Z inc consumption (20, 30, 50, 70, 100 mg/kg/day) don't have effect on motor activity of their female offspring. Also, Aluminum consumption (200,400,600 mg/kg/day) don't have effect on motor activity of t heir offspring but 800 mg/kg/day significantly (p<0.05) impairs motor activity. These studies have demonstrated that consumption of 800 mg/kg/day AlCl 3 during lactation, can impairment coordination of th eir male and female offspring. But different doses of ZnCl 2 administration don’t have effect on motor activity on their male a nd female offspring.

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