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The detection of telomerase activity in the differential diagnosis of pancreatic mass| Abstract

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The detection of telomerase activity in the differential diagnosis of pancreatic mass

Abstract

Ksenia Russkova

This research builds on the known role of telomerase activity in cancerogenesis, and we use it to determine the effectiveness of telomerase activity to differentially diagnosis a pancreatic mass. We show that the detection of telomerase activity in pancreatic mass tissue provides early evidence of a cancerous process that requires a well-timed surgical treatment. Eighty-eight patients with pancreatic mass (both benign and malignant) were involved in the research. Comparative analyses of the data and instrumental methods to define the histological structure of tumor mass and measure telomerase activity have been carried out. Intense telomerase activity (+++) in the tissue of pancreatic mass determines cancer with high accuracy. 100%of patients with pancreatic cancer had high telomerase activity. In 32,4% of patients with average telomerase activity (++) pancreatic cancer was diagnosed. The average telomerase activity (++) in pancreatic tumors gives an early indication of pancreatic cancer and requires dynamic observation for six to 12 months. Low telomerase activity (+) in patients with benign tumors is an accurate sign for confirming a diagnosis This method will improve the quality of diagnosis and treatment for patients with pancreatic tumors. .

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