Aniruddha Chatterjee1#a,b * and Anindya Basu 2
Ribulose-1, 5-bisphosphate carboxylase-oxygenase (Rubisco) is the principal catalyst for photosynthesis and is the basic means by which living creatures acquire the carbon necessary for life. Yet, with a turnover rate of 3 sec-1, Rubisco is one of the slowest enzymes known for various reasons. Re-engineering of the enzyme leads to the improvement of the functional property to optimize its activity. An ideal engineering strategy combines Bioinformatics and computational modelling with our knowledge of the natural variation in Rubisco sequence, structure and activity to help fine tune the design process. Improved Rubisco holds promise to bring renaissance in global agriculture
Share this article