International Research Journal of Biotechnology

Hyperuricemia is now an established factor to cause oxidative stress, insulin resistance and systemic inflammation. So it is likely that hyperuricemia might be involved in hepatic necroinflammation and destruction which are the common underlying pathophysiology of cirrhosis. On the other hand, as uric acid is the end product of cellular degradation, increased hepatocyte destruction due to any etiology increases the level of serum uric acid which might further aggravate hepatic necroinflammation, cirrhosis & complications. Objectives: To assess serum uric acid concentrations in patients of cirrhosis of the liver and its relation with cirrhosis of different etiology, disease severity, and liver enzymes. This cross-sectional observational study was carried out in the Department of Gastroenterology, BSMMU, Bangladesh. A total of 220 diagnosed cases of cirrhosis of the liver due to any cause were enrolled as the study population. Serum uric acid level was measured in each patient and its relationship with different etiology of cirrhosis, severity of cirrhosis and liver enzymes were assessedaetiology (431ms)