Prevalence and characteristics of resistant hypertension among Greek type 2 diabetic subjects| Abstract


Prevalence and characteristics of resistant hypertension among Greek type 2 diabetic subjects


A. Papazafiropoulou, A. Sotiropoulos, A. Kokolaki, S. Bousboulas, M. Kardara, S. Pappas

It is well documented that hypertension is more prevalent among type 2 diabetic (T2D) subjects. Successful tight blood pressure control allows to significantly reducing the incidence of microvascular and cardiovascular complications in T2D subjects; unfortunately, adequate blood pressure control is reportedly not achieved in up to 50–75% of diabetic patients. Therefore, we performed a retrospective analysis in order to estimate the prevalence of resistant hypertension among Greek T2D subjects. We performed a retrospective analysis of the medical records of 664 T2D subjects (mean age ± standard deviation: 65.5 ± 9.8 years, 341 females / 323 males) with arterial hypertension attending the diabetes outpatient clinic of our hospital during the period from 1 January 2010 to 30 September 2010. Of the study participants, 20.8% (n=138) had resistant hypertension. The antihypertensive treatment of the diabetic subjects with and without resistant hypertension was, respectively; 59.4% vs. 47.9% on angiotensin-converting enzyme inhibitors (ACE-I) (P=0.01), 45.7% vs. 21.9% on angiotensin II receptor blockers (ARBs) (P<0.001), 52.2% vs. 23.0% on β-blockers (P<0.001), 12.3% vs. 1.5% on centrally acting antihypertensives (P<0.001), and 71.0% vs. 29.7% on calcium channel blockers (P<0.001). Of the diabetic subjects without resistant hypertension 39.53% was on treatment with diuretics. Multivariate logistic analysis adjustment resistant hypertension was associated with body mass index (BMI) (OR: 1.06, 95% CI: 1.02-1.11, P<0.001), presence of coronary artery disease (OR: 1.83, 95% CI: 1.21-2.77, P=0.004), and insulin therapy (OR: 1.78, 95% CI: 1.15-2.75, P=0.01). In conclusion, the present study showed that a significant percentage of T2D subjects have resistant hypertension that is related with body mass index, presence of coronary artery disease and insulin treatment.

Share this article


tempobet girişbursa escort

tempobet giriş

tempobet giriş linki tipobet e yeni giriş tipobet e yeni giriş tipobet son giriş süpertotobet güncel