Munawar Iqbal, Muhammad Mushtaq, Mazhar Abbas, Muhammad Afzal and Syed Makhdoom Hussain
The present study was conducted for evaluation of biokinetics of cefaclor following oral administration of 1 g cefaclor (CCL) tablet in male volunteers. The blood samples of male volunteers were collected for the period of 10 h in heparinized tubes for stipulated period of time, centrifuged (3000xg) and plasma thus separated was stored at -10°C for microbiological assay. The CCL plasma concentration was determined following disc diffusion method against four bacterial strains, namely Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pasteurella multocida. The biokinetics parameter was measured using American Pharmacology Organization (APO) software. Four bacteria were found highly susceptible to CCL and from biokinetics study it is suggested that administration of CCL of 1 g (500 mg q 12 h-1) daily maintained a considerable concentration that proved it to be very effective for the treatment of bacterial infections understudy in male volunteers.
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