Invitro susceptibility test of Candida spp. isolates from pu | 17930
International Research Journals

Invitro susceptibility test of Candida spp. isolates from pulmonary tuberculosis suspected patientsto antifungal agents in Jakarta


Widyasari Kumala and Mardiastuti H.W

Pulmonary infection is still a major health concern in Indonesia, and fungal infection is emerging. Th is may be related to widely used broad spectrum antibi otics, steroids, oral contraceptive, cytostatic, an d chronic diseases.The aim of this study was to descr ibe Candida spp sensitivity pattern to various antifungal agents from pulmonary tuberculosis suspe cted patients. In this study, we used 176 sputum samples from tuberculosis suspected patients. The s amples were cultured 3 times in Sabouraud dextrose agar. Yeast was identified by API 20 C AUX , while antifungal susceptibility test used ATB FUNGUS 3. There were 85 samples infected by yeast. As many as 74 isolates were identified as C. albicans (87.1%), 9 isolates were C. tropicalis (10.6%) and 2 were C. dubliniensis (2.4%). The susceptibility test showed six isolates of C. albicans and one isolate of C. tropicalis were intermediate against itraconazole. Only three isolates of C. albicans were resistant against itrazonazole, fluconazole, and voriconazole. Fortunately, they we re still sensitive to amphotericine B and flucytosine. Almost half of tuberculosis suspected patients were infected by Candida spp. Most of them were still sensitive to various antifungal age nts, although few C. albicans isolates were resistant against fluconazole, itraconazole, voriconazole.

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