From a biological view, most of the processes involved in insulin resistance, which drives the pathobiology of type 2 diabetes, are reversible. This theoretically makes the disease reversible and curable by changing dietary habits and physical activity, particularly when adopted early in the disease process. Yet, this is not fully implemented and exploited in health care due to numerous obstacles. This article reviews the state of the art in all areas involved in a diabetes cure-focused therapy and discusses the scientific and technological advancements that need to be integrated into a systems approach sustainable lifestyle-based healthcare system and economy. The implementation of lifestyle as cure necessitates personalized and sustained lifestyle adaptations, which can only be established by a systems approach, including all relevant aspects. Introduction of such a systems approach in type 2 diabetes therapy not only requires a concerted action of many stakeholders but also a change in healthcare economy, with new winners and losers. A “call for action” is put forward to actually initiate this transition. The solution provided for type 2 diabetes is translatable to other lifestyle-related disorders. Metabolism is a term that refers to the complex biochemical processes that occur within an organism in order to sustain life. These processes include the conversion of food into energy, the synthesis of complex molecules, and the breakdown of waste products. Metabolism is an essential part of all living organisms, from single-celled bacteria to complex multicellular animals. The concept of metabolism dates back to the ancient Greeks, who believed that the body's metabolic processes were controlled by a balance of four bodily fluids, or "humors": blood, phlegm, yellow bile, and black bile. It wasn't until the 19th century that scientists began to study metabolism in a more systematic way, and it wasn't until the 20th century that the underlying biochemical mechanisms were fully understood.
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