Contagious Bovine pleuropneumonia protein squence analysis | 17593
International Research Journals

International Research Journal of Biochemistry and Bioinformatics

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Contagious Bovine pleuropneumonia protein squence analysis


Ayuba Dauda , Abdulmojeed Yaku , Ihe Ndu Dim and Gwaza Deeve Seebastian

A total of forty (20) contagious bovine pleuropneumonia (CBPP) proteins were retrieved from the GenBank ( The Genbank accession numbers of the sequences and sequence variations of the proteins were used to investigate the molecular identity of various CBPP proteins. The physico-chemical properties of CBPP proteins were performed using protparam tool. Isoelectric point (pI), molecular weight (MW), extinction coefficient (EC); instability index (II), aliphatic index (AI) and grand average of hydropathicity (GRAVY) were computed. The study also revealed that some of the pis of CBPP proteins were acidic while some were basic in nature. The EC and II of CBPP proteins indicate better stability which is an indication of resistant to mutation. AI for some of CBPP protein have AI>100. This indicates thermo stability of the protein. The GRAVY of CBPP proteins revealed some are positive while some are negative. The positive value indicates solubility (hydrophilic) in water while negative is not soluble (hydrophobic) in water. The amino acid composition of CBPP proteins indicates that they are rich in isoleucine, leucine and lysine. The three dimensional structures (3D) of the CBPP proteins were determine using Phyre2 server. The amino acid sequences of CBPP proteins were subjected to secondary structure prediction using ExPASy�?¢�?�?��?�?�s SOPMA tool. The proteins are more of alpha helix structure. The genetic information revealed in this study will help in carrying out research in mutagenesis and pharmacogenetic so as to increase cattle production and also to eliminating transboundary trade bearier in developing countries.

Share this article