Comparative protein profiling of antibiotic resistant S. aur | 17662
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International Research Journal of Microbiology

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Comparative protein profiling of antibiotic resistant S. aureus strains from hospital and community- associated infections


Torimiro N, Ako-Nai AK and Omitogun OG

The study compared antibiotic resistance pattern of community and hospital associated Staphylococcus aureus strains in order to evaluate the relationship between the strains. The strains were identified from a total of 150 specimens collected from human subjects using standard bacteriological methods. The antibiotic susceptibility pattern was determined using the disk diffusion plating method. The whole cell protein profile was determined using 10% sodium dodecylsulphatepolyacrylamide gel electrophoresis. A total of 107(71.3%) S. aureus isolates were identified. In all, 67 (62.6%) of the isolates were cultured from the hospital while 40 (37.4%) of the isolates were cultured from the community. The incidence of antibiotics resistance was high in both settings. But 9 of the strains were resistant to methicillin/oxacillin. The protein profiling of the methicillin resistant strains, showed that 2 strains from the community clustered in the hospital phenon. Dissemination of resistant strains appears to be based mainly on clonal spread; indiscriminate use of anti-infective agents is secondary. Hence, effective infection control measures are important.

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