The plants are rich in anti-microbial agents for their anti-microbial activity. In this study, the powdered leaves extracts of Ixora coccinea and Datura metel were macerated and extracted with solvents in acetone, methanol and iso-propanol. The study was done to evaluate the anti-microbial property of leaf extracts of Ixora coccinea and Datura metel against the bacterial strain of Escherichia coli and Staphylococcus aureus by agar well diffusion method. From the antimicrobial activity assay, the best zone of inhibition formation of 11.8 ± 0.64 mm was observed in the case of Ixora coccinea against the bacterial strain of Escherichia coli whereas Datura metel had shown good anti-bacterial activity against Staphylococcus aureus by the inhibition zone formation of 15.3 ± 0.27 mm. These results showed that Escherichia coli have an excellent susceptibility against Ixora coccinea, wherein Staphylococcus aureus showed susceptibility against Datura metel. These results revealed that acetone extracts of these plants leaves have antibacterial activity against the tested organisms than the other used extracts for the experimental studies. Auxiliary studies should be started to interpret the action mechanism of antimicrobial effect in order to detect the active ingredients which in turn can be utilized in drug development.
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