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Chaotic cardiac law: Developing predictions of clinical application| Abstract

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Chaotic cardiac law: Developing predictions of clinical application

Abstract

Javier Rodríguez, Catalina Correa, Martha Melo, Darío Domínguez, Signed Prieto, Diana Margarita Cardona, Yolanda Soracipa, Jessica Mora

Cardiac chaotic dynamics have been evaluated from d ynamic system theory, fractal geometry, and a power law that deduces all possible discrete chaoti c attractors allowing the development of a diagnostic method with clinical application. To con firm the clinical applicability of the diagnostic method based on the exponential law in normal and w ith different cardiac pathologies cardiac dynamics, heart rates and number of beats per hour from 115 Holters were measured: 15 diagnosed as normal and 100 with different pathologies, in order to build a blind study. Attractors were constructe d to calculate fractal dimension through the box-coun ting method, and their respective occupation spaces were quantified. These values were used to d etermine the mathematical physical diagnosis based on the power law. Subsequently, the diagnosti c concordance respect to the Gold Standard was evaluated by calculating specificity, sensitivity a nd Kappa coefficient. Normal cases were differentia ted from those with various pathologies, obtaining sens itivity and specificity of 100% and Kappa coefficie nt of 1. The applicability of the methodology for the clinical diagnosis of cardiac dynamics was confirme d. The cardiac chaotic attractors evaluated with an ex ponential law show a causeless self-organization of cardiac dynamics that allow predicting the clinical diagnosis.

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