Shyam Vinay Sharma
The arterial baroreflex regulate the blood pressure and maintain circulation to the brain and other organs. Baroreceptors sense systemic blood pressure indirectly, by the extent of stretch of receptors in the walls of the carotid arteries and of the aorta. Lead (Pb) exposure continues to be a major public health problem; particularly in urban area of the USA and India Lead enters astroglia and neurons via voltage-sensitive calcium channels. Lead disrupts calcium homeostasis, causing a marked accumulation of calcium in lead-exposed cells. Thus lead (Pb) can modulate various reflexes of the body including baroreflex. In present study we indirectly assess the baroreflex sensitivity (BRS) by quantifying sinus arrhythmia and change in blood pressure induced by volunteer apnea and change in posture. There was a significant increase in the HR when the posture changed from supine to standing, being highest in standing this increase was more in control (79.43± 8.78) than cases. Our data showed that increase in heart rate in lead exposed persons was significantly lower than controls. Our study data suggests that Lead (Pb) exposure causes decrease in baroreflex sensitivity in battery workers which may leads to orthostatic hypotension and deregulation of cardiovascular hemodynamic
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