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International Research Journal of Plant Science

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Assessment of hepatoprotective and antioxidant activity of nauclea latifolia leaf extract against acetaminophen induced hepatotoxicity in rats

Abstract

Effiong, G.S, Udoh, I.E, Udo, N.M, Asuquo, E. N, Wilson, L. A, Ntukidem, I.U. and Nwoke, I.B.

The present study was carried out to evaluate the hepatoprotective and antioxidant effect of the ethanol extract of Nauclea latifolia (NL) leaf in Wistar albino rats. Protective action of (NL) leaf extracts was evaluated using animal model of hepatotoxicity induced by Acetaminophen (Paracetamol) (2 g/kg, bw p.o). Liver marker enzymes and antioxidant status were assayed in serum. Histopathology was also studied while silymarin was used as the standard drug for this study. Levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were increased and the levels of total protein and albumin were decreased in Acetaminophen treated rats. NL leaf at (400 mg/kg, bw) doses decreased the elevated levels of the transaminases and restored the normalcy of total protein (TP) and albumin significantly. The activities of catalase (CAT), glutathione Peroxidase (GPx) and superoxide dismutase (SOD) were decreased in hepatotoxic rats but administration with NL leaf extract increased the GPx, CAT and SOD. Histopathology shows restoration of the Acetaminophen damaged liver with NL administration. From this study it can be concluded that the NL leaf showed significant hepatoprotective and antioxidant action.

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