Franck Mansour Ad�?éoti Camara-Ciss�?é Massara , Yves Emery Th�?é, Bernard Nazaire Djyh, Innocent Kouam�?é Kolia, Joseph Allico Djaman, Daniel Essagne Sess
The interest of peoples for medicinal plants continues to grow. Among these plants, Mansonia altissima is used against leprosy and tuberculosis. The aim of this study was to evaluate antioxidant, hypolipidemic and cardioprotective effects of chloroform extract from Mansonia altissima in rabbits. Increasing doses (4.7-75 mg/kg) of chloroform extract were administered in 36 rabbits. Antioxidant activity was evaluated by indirect determination of free radicals (TBARS) using modified method of Yagi and the total antioxidant power by the test of reduction of iron FRAP Benzie and Strain. Serum triglycerides, total cholesterol, HDL and LDL cholesterols were perfumed with multiparatemers analyzer. We noted a significant decrease (P < 0.05) concentration of TBARS (2.42-2.25 nmol/L of MDA) in plasma. It also noted a significant increase (P < 0.01) in time the total antioxidant power (22-27 mmol/L of Fe2+) of extract at non-lethal doses. A beneficial effect was also observed on the atherogenic risk with a significant decrease in plasma of total cholesterol, triglyceride and LDL-cholesterol concentrations, associated with a cardio protective effect resulting of HDL-cholesterol and atherogenic index elevation. Chloroform extract of M. altissima has antioxidant hypolipidemic and cardio protective properties in rabbits.
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