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International Research Journal of Microbiology

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1,3,4-oxadiazole and selenadiazole derivatives as new C-Glycosyl analogs with MAO-B, antibacterial and antifungal activities

Abstract

Mohamed Mohamed El Sadek *, Nagwa Said Abd El-Dayem , Seham Yassen Hassan and Galila Ahmed Yacout

Acetylation of the carbohydrazide derivative 3 afforded the di-N-acetyl-tetra-O-acetyl derivative 4, while condensation with a variety of aldehydes gave the corresponding carbohydrazones 6a-e. Oxidative cyclization of the O-acetylated hydrazones 7a,b afforded the 1,3,4-oxadiazoles 8a,b respectively. Periodate oxidation of 6a-d gave the corresponding formyl derivatives 10a-d, which on reduction resulted in the hydroxymethyl derivatives 11a-d respectively. Prolonged acetylation of the carbohydrazone 11b resulted in 2,3-dihydro-1,3,4-oxadiazole-O-acetyl derivative 12b2. Cyclization of the semicarbazone 14 afforded 1,2,3-selenadiazole 16. Methylation of compound 17 afforded 1-[5-(2',3'- dimethoxytetrahydrofuran-1'-yl)-1,2-dimethyl-1H-pyrol-3-yl]ethanone 18. Furthermore, two of the prepared compounds were examined to show the ability to activate MAO-B with different values. In addition a number of prepared compounds showed antibacterial and antifungal activities.

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