Therapeutic efficacy of Tapinanthus globiferus on acetaminop | 16955
International Research Journals

International Research Journal of Biochemistry and Bioinformatics

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Therapeutic efficacy of Tapinanthus globiferus on acetaminophen induced nephrotoxicity, inflammatory reactions and oxidative stress in albino rats


Adekunle A.S, Oyewo B.E and Afolabi O.K.

Nephrotoxicity due to acetaminophen toxicity has been reported in many studies. This study was therefore designed to access the nephro-protective effect of Tapinanthus globiferus on possible acetaminophen-induced nephrotoxicity. There were elevations in markers of inflammation namely tumor necrotic factor alpha and interleukin 2 and activities of gamma glutamyl transferase in groups given different doses of acetaminophen when compared with control. Serum concentrations of creatinine and urea were elevated in rats given acetaminophen. Serum concentrations of total proteins and albumin were reduced in groups given different doses of acetaminophen. However, all the side effects were ameliorated in rats given Tapinanthus globiferus alongside acetaminophen. The study showed that administration of Tapinanthus globiferus reduced damages due to acetaminophen administrations either at normal or higher doses. In this study, Tapinanthus globiferus exhibited nephro-protective, anti-inflammatory and anti-oxidative properties.

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