Pseudomonas aeruginosa is an opportunistic human pathogen that can cause severe acute and chronic infections in people whose immune systems are compromised. Its capacity to form biofilms that are resistant to antibiotics is to blame for its well-known persistence in clinical settings. Biofilm is a structure that is mostly made of autogenic extracellular polymeric substances. It serves as a scaffold to hold the bacteria together on surfaces, protects them from environmental stresses, prevents phagocytosis, and gives them the ability to colonize and stay in the same place for a long time. P. aeruginosa biofilms, their stages of development, and the molecular mechanisms by which biofilms invade and persist are reviewed in this article. Explosive cell lysis within bacterial biofilms to produce essential communal materials, as well as interspecies biofilms of P. aeruginosa and commensal Streptococcus that prevent P. aeruginosa from becoming virulent and may even improve disease conditions, will also be discussed. Late examination on diagnostics of P. aeruginosa diseases will be researched. In the end, therapeutic strategies for treating P. aeruginosa biofilms will be compiled, along with their benefits and drawbacks.
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