|International Research Journal of Pharmacy and Pharmacology (ISSN 2251-0176) Vol. 5(1) pp. 1-7, June 2015. DOI: http:/dx.doi.org/10.14303/irjpp.2015.052. Copyright © 2015 International Research Journals
Full Length Research Paper
Evaluation of anti-inflammatory activity of aqueous extract of medicinal preparation constitute of three plants in the rat wistar
*Okémy Andissa N, Mouankié J. B, Abena A.A, Gbeassor M
1Laboratory of Biochmical and Pharmacology, Faculty of Sciences and Health, Marien NGOUABI,University of Congo
2Cerfoplam, University of Lomé, B.P. 1515, Lomé-Togo
*Corresponding author’s email: email@example.com
Received March 17, 2015; Accepted May 8, 2015
Aqueous extract of an preparation constitute of three medicinal plants produced a significant reduction in wistar rats volume edema induced by carrageenan 2%, and an increase granuloma formation induced by implantation of cotton pellet under the under the aponevrose of the posterior leg of wistar rats. This extract of the preparation, without limit none dose dependently vascular permeability (100 mg / kg), also blocked the migration of leukocytes to the inflammation site and shows a significant antioxidant activity. Phytochemical study revealed the presence in this extract of flavonoïds, tannins and saponins which could support the anti-inflammatory effect. The proposed formulation with this aqueous extract is also active in acute inflammation.
Key words: Preparation, Medicinal plants, Treatment, anti inflammatory.