International Research Journal of Pharmacy and Pharmacology

International Research Journal of Pharmacy and Pharmacology Vol. 2(1), pp.001-009 January  2012         
Copyright © 20112International Research Journals

 

Review

Antitubercular drug discovery: the molecular modification as promise tool

Luiz Antonio Dutra1;   Thais Regina Ferreira de Melo1; Chung Man Chin1; Jean Leandro dos Santos1

Lapdesf–Laboratório de Pesquisa e Desenvolvimento de Fármacos, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas – Universidade Estadual Paulista–UNESP, Rodovia Araraquara Jaú Km. 01, 14801-902, Araraquara, SP, Brazil;

*Corresponding author email: dutrala@fcfar.unesp.br  

Received 30 November 2011; Accepted 05 December, 2011

Abstract

Tuberculosis is a chronic infectious disease caused by etiologic agent Mycobacterium tuberculosis. "It has been reported that rates of incidence is increasing and each year around 8.9-9.9 million new cases are detected”. The current TB therapy presents several problems such as long-term therapy, drug resistance, no-compliance to therapy and few therapeutic sources to treat the disease. The discovery of new drugs safer and more efficient is urgent. The molecular modification is an important tool that allows discovering new compounds that can be win these challenges. In this work, we summarize the main strategies useful to obtain a new antitubercular drug.

Keywords: Tuberculosis; antitubercular drugs; new drugs; molecular modification.

 

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