International Research Journal of Biochemistry and Bioinformatics

International Research Journal of Biochemistry and Bioinformatics (ISSN-2250-9941) Vol. 6(1) pp.001-006, December, 2016. DOI: http:/dx.doi.org/10.14303/irjbb.2016.100. Copyright © 2016 International Research Journals  

 

Full Length Research Paper

Antioxidant, hypolipidemic and cardio-protective properties of chloroform extract of Mansonia altissima (Sterculiaceae) in rabbits

Franck Mansour Adéoti1,2*, Camara-Cissé Massara 2, Yves Emery Thé1, Bernard Nazaire Djyh3, Innocent Kouamé Kolia1, Joseph Allico Djaman3, Daniel Essagne Sess2

1 Laboratory of medical biochemistry, University Hospital Center of Yopougon, 2 Laboratory of medical biochemistry, UFR of medical sciences, Félix Houphouët-Boigny University/Abidjan, 3 Laboratory of pharmacodynamics-biochemistry, UFR Biosciences, Félix Houphouët-Boigny University/Côte d’Ivoire

Corresponding Author’s E-mail: adeotimfranck@gmail.com , Tel: 00 225 08 40 72 93

Received October 17, 2016;  Accepted November 15, 2016

Abstract               

 

The interest of peoples for medicinal plants continues to grow. Among these plants, Mansonia altissima is used against leprosy and tuberculosis. The aim of this study was to evaluate antioxidant, hypolipidemic and cardioprotective effects of chloroform extract from Mansonia altissima in rabbits. Increasing doses (4.7-75 mg/kg) of chloroform extract were administered in 36 rabbits. Antioxidant activity was evaluated by indirect determination of free radicals (TBARS) using modified method of Yagi and the total antioxidant power by the test of reduction of iron FRAP Benzie and Strain. Serum triglycerides, total cholesterol, HDL and LDL cholesterols were perfumed with multiparatemers analyzer. We noted a significant decrease (P < 0.05) concentration of TBARS (2.42-2.25 nmol/L of MDA) in plasma. It also noted a significant increase (P < 0.01) in time the total antioxidant power (22-27 mmol/L of Fe2+) of extract at non-lethal doses. A beneficial effect was also observed on the atherogenic risk with a significant decrease in plasma of total cholesterol, triglyceride and LDL-cholesterol concentrations, associated with a cardio protective effect resulting of HDL-cholesterol and atherogenic index elevation. Chloroform extract of M. altissima has antioxidant hypolipidemic and cardio protective properties in rabbits.

 

Keywords: Mansonia altissima, Antioxidant, Cardio-protective, Lipideminic

 

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