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Full Length
Research Paper
Cell-mediated immunity in Type 2 diabetes mellitus patients
in diabetic ketoacidosis, patients with controlled Type 2
diabetes mellitus and healthy control subjects.
Musa, B. O. P.1,
Onyemelukwe, G.C.1, Hambolu, J. O.2,
Bakari, A.G.3, Anumah, F.E.3
1Immunology
Unit, Department of Medicine, A.B.U.T.H. Zaria,
2Department
of Veterinary Anatomy, Faculty of Veterinary Medicine,
Ahmadu Bello University, Zaria and 3Endocrinology
Unit, Department of Medicine, A.B.U.T.H. Zaria, Nigeria.
*Corresponding author e-mail:
bolamusa2002@yahoo.com
Received 14 April, 2010; Accepted 19 July, 2010
Immune modulation accompanying metabolic dysfunction can
adversely affect outcome of a non infectious disease such as
type 2 diabetes mellitus (T2DM).
Peripheral T lymphocyte subsets were analyzed with
monoclonal antibodies via manual counting by the indirect
immunofluorescence method, in type 2 Diabetes mellitus
patients in DKA, controlled T2DM patients as well as normal
healthy controls (NHC).There was a significant decrease in
CD4+ T cells alongside a non significant increase
in CD8+ T cells in patients with diabetic
ketoacidosis (DKA) compared to controlled T2DM patients and
normal healthy controls. Ratio of CD4/CD8+ T cells was also
lowest in DKA.These T cell changes in patients with DKA
reflect an abnormal immunoregulatory mechanism in
parallel with an impaired metabolic process and
may lead to enhanced beta cell damage and increased
susceptibility to DKA crisis in T2DM patients.
Keywords: Cell mediated immunity, diabetic
ketoacidosis, Type 2 diabetes mellitus, metabolic
dysfunction, T lymphocytes |